Hypersensitivity to nonsteroidal antiinflammatory drugs presents a life-threatening hazard to some patients with asthma and an opportunity to further unravel the primary mechanisms underlying respiratory and cutaneous diseases. With our present state of knowledge, the practitioner should counsel patients with rhinosinusitis/nasal polyps/asthma to avoid aspirin and aspirin-like drugs. Only occasionally will it be necessary to perform oral challenge with these drugs for the purpose of patient management. If there is to be progress in the clinical investigation of hypersensitivity to nonsteroidal antiinflammatory drugs, investigators will need to report the details of clinical findings in their populations of asthma and urticaria patients undergoing challenges. especially concerning whether or not their patients are taking other drugs, the doses and timing of the aspirin or aspirin-like drug used in challenges, and the measurements of bronchopulmonary function and other parameters following oral challenge.
Mathison, D. A., & Stevenson, D. D. (1979). Hypersensitivity to nonsteroidal antiinflammatory drugs: Indications and methods for oral challenges. The Journal of Allergy and Clinical Immunology, 64(6 PART 2), 669–674. https://doi.org/10.1016/0091-6749(79)90036-8