Hypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions

45Citations
Citations of this article
107Readers
Mendeley users who have this article in their library.

Abstract

Hypoxia inducible transcription factors (HIFs) activate diverse pathways that regulate cellular metabolism, angiogenesis, proliferation, and migration, enabling a cell to respond to a low oxygen or hypoxic environment. HIFs are regulated by oxygen-dependent and independent signals including: mitochondrial dysfunction, reactive oxygen species, endoplasmic reticular stress, and viral infection. HIFs have been reported to play a role in the pathogenesis of liver disease of diverse aetiologies. This review explores the impact of HIFs on hepatocellular biology and inflammatory responses, highlighting the therapeutic potential of targeting HIFs for an array of liver pathologies.

Cite

CITATION STYLE

APA

Wilson, G. K., Tennant, D. A., & McKeating, J. A. (2014, December 1). Hypoxia inducible factors in liver disease and hepatocellular carcinoma: Current understanding and future directions. Journal of Hepatology. Elsevier. https://doi.org/10.1016/j.jhep.2014.08.025

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free