Icacina senegalensis (Icacinaceae), traditionally used for the treatment of malaria, inhibits in vitro Plasmodium falciparum growth without host cell toxicity

14Citations
Citations of this article
47Readers
Mendeley users who have this article in their library.

Abstract

Background: With the aim of discovering new natural active extracts against malaria parasites, Icacina senegalensis was selected after an ethnopharmacological survey conducted on plants used in traditional malaria treatment in Senegal. Methods. Different concentrations of the plant extract and fractions were tested on synchronized Plasmodium falciparum cultures at the ring stage using the parasite lactate dehydrogenase assay. Their haemolytic activity and in vitro cytoxicity were evaluated. The chromatographic profiles of active fractions were also established. Results: The plant extract and fractions revealed anti-plasmodial activity (IC50< 5 μg/mL) with no toxicity (Selectivity indexes >10). The dichloromethane fraction showed stronger anti-plasmodial activity than the total extract. Conclusion: Anti-plasmodial activity and toxicity of I. senegalensis are reported for the first time and showed promising results in malaria field research. © 2011 Sarr et al; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Sarr, S. O., Perrotey, S., Fall, I., Ennahar, S., Zhao, M., Diop, Y. M., … Marchioni, E. (2011). Icacina senegalensis (Icacinaceae), traditionally used for the treatment of malaria, inhibits in vitro Plasmodium falciparum growth without host cell toxicity. Malaria Journal, 10. https://doi.org/10.1186/1475-2875-10-85

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free