Identification and analysis of Hic-5/ARA55 isoforms: Implications for integrin signaling and steroid hormone action

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Abstract

Hic-5/ARA55 is a LIM-only member of the paxillin superfamily. Conflicting reports have suggested that Hic-5/ARA55 can both repress and enhance a number of biological processes, including myogenesis and tumorigenesis. With two Hic-5 isoforms documented, we hypothesized that multiple Hic-5 isoforms may exist that have both overlapping and isoform-specific functions. To test this hypothesis, we performed an extensive analysis of Hic-5 transcripts in both cell lines and mouse tissues and found 12 distinct isoforms that fall into two sub-families. These isoforms are derived from both alternative splicing and alternative transcriptional start sites (TSS). Hic-5 expression is regulated in a temporally and spatially controlled manner in vivo. The identification of numerous Hic-5 isoforms suggests that Hic-5 subsumes a number of distinct roles in cells and may explain the range of biological responses attributed to Hic-5. © 2005 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

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Gao, Z., & Schwartz, L. M. (2005). Identification and analysis of Hic-5/ARA55 isoforms: Implications for integrin signaling and steroid hormone action. FEBS Letters, 579(25), 5651–5657. https://doi.org/10.1016/j.febslet.2005.08.086

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