Transcriptional regulation plays an important role in the control of many biological processes. Transcription factor binding sites (TFBSs) are the functional elements that determine transcriptional activity and are organized into separable cis-regulatory modules, each defining the cooperation of several transcription factors required for a specific spatio-temporal expression pattern. Consequently, the discovery of novel TFBSs in promoter sequences is an important step to improve our understanding of gene regulation.
Vandepoele, K., Casneuf, T., & Van de Peer, Y. (2006). Identification of novel regulatory modules in dicotyledonous plants using expression data and comparative genomics. Genome Biology, 7(11). https://doi.org/10.1186/gb-2006-7-11-r103