IFN-γ cannot substitute lack of IFN-γ responsiveness in cells of an IFN-γR1 deficient patient

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Patients with complete IFN-γR deficiency are unable to respond to IFN-γ and have impaired Th1-immunity and recurrent, severe infections with weakly virulent Mycobacteria. Since IFN-α and IFN-γ share signalling pathways, treatment with IFN-α has been proposed in complete IFN-γR deficiency. We stimulated cells from healthy controls and from a patient lacking IFN-γR1 with IFN-α and IFN-γ, to establish whether IFN-α would substitute for IFN-γ effects. IFN-α induced STAT1 phosphorylation in monocytes of the IFN-γR1-/- patient, but did not prime for LPS-induced IL-12p70, IL-12p40, IL-23 or TNF production. In control cells, IFN-γ inhibited the priming effect of IFN-γ on LPS-induced pro-inflammatory cytokine release. Finally, IFN-γ but not IFN-α induced killing of M. smegmatis in cultured macrophages. In conclusion, no evidence was found to support the use of IFN-α in IFN-γR-deficient patients as intervention against mycobacterial infection; on the contrary, treatment of individuals with IFN-α may even adversely affect host defence against Mycobacteria. © 2010 Elsevier Inc.




de Wetering, D. van, van Wengen, A., Savage, N. D. L., van de Vosse, E., & van Dissel, J. T. (2011). IFN-γ cannot substitute lack of IFN-γ responsiveness in cells of an IFN-γR1 deficient patient. Clinical Immunology, 138(3), 282–290. https://doi.org/10.1016/j.clim.2010.12.005

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