IL-17A, MCP-1, CCR-2, and ABCA1 polymorphisms in children with non-alcoholic fatty liver disease

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Abstract

Objective: The prevalence of non-alcoholic fatty liver disease in children has risen significantly, owing to the worldwide childhood obesity epidemic in the last two decades. Non-alcoholic fatty liver disease is closely linked to sedentary lifestyle, increased body mass index, and visceral adiposity. In addition, individual genetic variations also have a role in the development and progression of non-alcoholic fatty liver disease. The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G)(rs1024611), CCR-2 (190 G/A)(rs1799864), ABCA1 (883 G/A)(rs4149313), and IL-17A (-197 G/A)(rs2275913)in obese Turkish children with non-alcoholic fatty liver disease. Methods: The study recruited 186 obese children aged 10–17 years, including 101 children with non-alcoholic fatty liver disease and 85 children without non-alcoholic fatty liver disease. Anthropometric measurements, insulin resistance, a liver panel, a lipid profile, liver ultrasound examination, and genotyping of the four variants were performed. Results: No difference was found between the groups in respect to age and gender, body mass index, waist/hip ratio, or body fat ratio. In addition to the elevated ALT levels, AST and GGT levels were found significantly higher in the non-alcoholic fatty liver disease group compared to the non non-alcoholic fatty liver disease group (p < 0.05). The A-allele of IL-17A (-197 G/A)(rs2275913)was associated with non-alcoholic fatty liver disease (odds ratio [OR]2.05, 95% confidence interval: 1.12–3.77, p = 0.02). Conclusions: The findings of this study suggest that there may be an association between IL-17A (-197 G/A)(rs2275913)polymorphism and non-alcoholic fatty liver disease development in obese Turkish children.

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Akbulut, U. E., Emeksiz, H. C., Citli, S., Cebi, A. H., Korkmaz, H. A. A., & Baki, G. (2019). IL-17A, MCP-1, CCR-2, and ABCA1 polymorphisms in children with non-alcoholic fatty liver disease. Jornal de Pediatria, 95(3), 350–357. https://doi.org/10.1016/j.jped.2018.03.005

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