Immobilization stress elevates IP 3 receptor mRNA in adult rat hearts in a glucocorticoid-dependent manner

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Abstract

Gene expression of the type 1 and 2 inositol 1,4,5-trisphosphate (IP 3 ) receptors in the rat cardiac atria and ventricles and their possible modulation by single immobilization stress was studied. Single immobilization stress significantly elevated mRNA levels for both types of these receptors. To evaluate the involvement of glucocorticoids in the modulation of the gene expression of IP 3 receptors by immobilization stress, we used adrenalectomized and/or hypophysectomized rats. Since adrenalectomy and/or hypophysectomy completely abolished increase in IP 3 receptor's mRNA levels after the immobilization, we conclude that immobilization stress elevates mRNA of type 1 and 2 IP 3 receptors, mainly through the glucocorticoid responsive element. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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Lencesova, L., Ondrias, K., Micutkova, L., Filipenko, M., Kvetnansky, R., & Krizanova, O. (2002). Immobilization stress elevates IP 3 receptor mRNA in adult rat hearts in a glucocorticoid-dependent manner. FEBS Letters, 531(3), 432–436. https://doi.org/10.1016/S0014-5793(02)03579-2

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