Multiple sclerosis (MS) is associated with the appearance of autoreactive T cells in the central nervous system. Using a mouse model of MS, Arima et al. now show that this attack begins at a specific spinal cord location. T cell entry into the CNS is regulated by a reflex neural circuit originating from leg muscle contractions.
Tracey, K. J. (2012). Immune Cells Exploit a Neural Circuit to Enter the CNS. Cell, 148(3), 392–394. https://doi.org/10.1016/j.cell.2012.01.025