Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development

277Citations
Citations of this article
40Readers
Mendeley users who have this article in their library.

Abstract

The compartment of mouse B cell progenitors can be resolved into five developmentally related fractions by multicolor flow cytometry. Using this system and employing mutant mice in which the membrane exon of the μ chain, the λ5 gene, or the JH locus was inactivated by gene targeting, we found that expression of the pre-B cell receptor complex is necessary for the transition from the large CD43+ to the small CD43- pre-B cell stage. We report the occurrence of immunoglobulin heavy and light chain gene rearrangement at the stage of large B cell precursors. We show that neither the pre-B cell receptor complex nor any gene rearrangement in the heavy chain locus is required for the induction of κ light chain gene rearrangement in early B cell progenitors. © 1993.

Cite

CITATION STYLE

APA

Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Müller, W., & Rajewsky, K. (1993). Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell, 72(5), 695–704. https://doi.org/10.1016/0092-8674(93)90398-A

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free