Impact of Alexithymia and Disease Characteristics on Work Productivity and Activity In Psoriasis Patients With Short Disease Duration: Epidepso Multicentre Study

  • Paul C
  • Girolomoni G
  • Radtke M
  • et al.
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Abstract

Alexithymia is the inability to describe and project emotions in the self. Our objective was to assess the association between alexithymia in psoriasis and loss of work productivity and activity in patients with psoriasis. EPIDEPSO (NCT01964443) is a 12-month observational international study to investigate alexithymia and other psychosocial comorbidities in psoriasis with a disease duration ≤ 10 years. Presence of alexithymia was defined as a score ≥ 61 on the 20-item Toronto Alexithymia Scale. Work productivity and activity were assessed using the Work Productivity and Activity Impairment Questionnaire: Psoriasis (WPAI-PSO). Clinical assessments and patient-reported outcomes included the Psoriasis Area and Severity Index (PASI) and the Dermatology Life Quality Index (DLQI). The data reported are from baseline analyses. The prevalence of alexithymia was 39{%} (95{%} confidence interval 35-43{%}). Alexithymic patients had higher unemployment rates than nonalexithymic patients (48{%} vs. 25{%}, P {<} 0.001; Fisher's exact test). WPAI-PSO results among employed patients showed comparable absenteeism between alexithymic and nonalexithymic patients, but more impairment at work (presenteeism) (29{%} vs. 13{%}). Productivity loss (34{%} vs. 17{%}) was greater in alexithymic than nonalexithymic patients. In both employed and unemployed patients there was greater activity impairment among alexithymic patients (38{%} vs. 20{%}, P {<} 0.001; Wilcoxon two-sample test for alexithymic vs. nonalexithymic). In the overall population, patients with a PASI score {>} 10 showed more impairment at work (24{%} vs. 15{%}), greater productivity loss (30{%} vs. 18{%}) and greater activity impairment (36{%} vs. 20{%}) than those with a PASI score ≤ 10 (all P {<} 0.01). Moderate correlations between DLQI and presenteeism (r = 0.56), productivity loss (r = 0.55) and activity impairment (r = 0.65, all P {<} 0.001) were identified. In patients with psoriasis, the inability to describe and project emotions may have an impact on daily work productivity and activity. Our data indicate that there is a complex relationship between alexithymia, disease severity and quality of life upon employment status and productivity. Janssen Pharmaceutica NV funded this study.

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APA

Paul, C., Girolomoni, G., Radtke, M., Sampogna, F., Spuls, P., Kirby, B., … Puig, L. (2015). Impact of Alexithymia and Disease Characteristics on Work Productivity and Activity In Psoriasis Patients With Short Disease Duration: Epidepso Multicentre Study. Value in Health, 18(7), A425–A426. https://doi.org/10.1016/j.jval.2015.09.583

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