Background: Cilostazol reduces restenosis and repeat revascularization after endovascular therapy (EVT) in claudicant patients with femoropopliteal lesions. However, the efficacy of cilostazol in patients with critical limb ischemia (CLI) is unclear. Therefore, we investigated the effect of cilostazol on outcomes in patients with CLI. Methods: From January 2004 to December 2009, 618 patients (30.8% women, 356 treated with cilostazol, 72.4 ± 7.3 years old) with CLI underwent EVT for de novo infrainguinal lesions. Their data were retrospectively analyzed. The primary outcome measure was amputation-free survival (AFS), The secondary outcome measures were overall survival, limb salvage, freedom from repeat revascularization, and freedom from surgical conversion. Mean follow-up was 21 ± 14 months. Results: AFS and the limb salvage rate at 5 years were significantly higher in the cilostazol-treated group (47.7% vs 32.7%, P
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Soga, Y., Iida, O., Hirano, K., Suzuki, K., Kawasaki, D., Miyashita, Y., … Nobuyoshi, M. (2011). Impact of cilostazol after endovascular treatment for infrainguinal disease in patients with critical limb ischemia. Journal of Vascular Surgery, 54(6), 1659–1667. https://doi.org/10.1016/j.jvs.2011.06.024
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