The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women

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Abstract

This study aimed to establish whether vigorous-intensity exercise offers additional adipose-related health benefits and metabolic improvements compared to energy-matched moderate-intensity exercise. Thirty-eight sedentary overweight men (n = 24) and postmenopausal women (n = 14) aged 52 ± 5 years (mean ± standard deviations [SD]) were prescribed a 3-week energy deficit (29302 kJ∙week-1) achieved by increased isocaloric moderate or vigorousintensity exercise (+8372 kJ∙week-1) and simultaneous restricted energy intake (+20930 kJ∙week-1). Participants were randomly assigned to either an energymatched vigorous (VIG; n = 18) or moderate (MOD; n = 20) intensity exercise group (five times per week at 70% or 50% maximal oxygen uptake, respectively). At baseline and follow-up, fasted blood samples and abdominal subcutaneous adipose tissue biopsies were obtained and oral glucose tolerance tests conducted. Body mass was reduced similarly in both groups (Δ 2.4 ± 1.1 kg and Δ 2.4 ± 1.4 kg, respectively, P < 0.05). Insulinemic responses to a standard glucose load decreased similarly at follow-up relative to baseline in VIG (Δ 8.6 ± 15.4 nmol.120 min.l-1) and MOD (Δ 5.4 ± 8.5 nmol.120 min.l-1; P < 0.05). Expression of SREBP-1c and FAS in adipose tissue was significantly down-regulated, whereas expression of PDK4 and hormone-sensitive lipase (HSL) was significantly up-regulated in both groups (P < 0.05). Thus, when energy expenditure and energy deficit are matched, vigorous or moderateintensity exercise combined with energy restriction provide broadly similar (positive) changes in metabolic control and adipose tissue gene expression.

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APA

Walhin, J. P., Dixon, N. C., Betts, J. A., & Thompson, D. (2016). The impact of exercise intensity on whole body and adipose tissue metabolism during energy restriction in sedentary overweight men and postmenopausal women. Physiological Reports, 4(24). https://doi.org/10.14814/phy2.13026

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