The impact of intrinsic ageing on the protein composition of the dermal-epidermal junction

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Abstract

The dermal-epidermal junction of human skin exhibits age-related remodelling, resulting in a flattened appearance and reduced surface area. Despite this, a paucity of information is available regarding which protein components change with advancing age. Here we report a significant reduction in the protein distribution of collagen IV (P < 0.0001), collagen VII (P < 0.001), collagen XVII (P < 0.01), integrin β4 (P < 0.001) and laminin-332 (P < 0.0001) in intrinsically aged skin. The functional implication of this altered protein composition appears to be loss of structural integrity and may, in part, explain the increased fragility of aged skin.

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Langton, A. K., Halai, P., Griffiths, C. E. M., Sherratt, M. J., & Watson, R. E. B. (2016). The impact of intrinsic ageing on the protein composition of the dermal-epidermal junction. Mechanisms of Ageing and Development, 156, 14–16. https://doi.org/10.1016/j.mad.2016.03.006

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