Impact of methoxyacetic acid on mouse Leydig cell gene expression

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Methoxyacetic acid (MAA) is the active metabolite of the widely used industrial chemical ethylene glycol monomethyl ether, which is associated with various developmental and reproductive toxicities, including neural toxicity, blood and immune disorders, limb degeneration and testicular toxicity. Testicular toxicity is caused by degeneration of germ cells in association with changes in gene expression in both germ cells and Sertoli cells of the testis. This study investigates the impact of MAA on gene expression in testicular Leydig cells, which play a critical role in germ cell survival and male reproductive function.




Bagchi, G., Zhang, Y., & Waxman, D. J. (2010). Impact of methoxyacetic acid on mouse Leydig cell gene expression. Reproductive Biology and Endocrinology, 8.

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