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Abstract

Of 38 vancomycin-intermediate Staphylococcus aureus (VISA) clinical strains, 27 (71{%}) possessed a mutation(s) in rpoB encoding the beta-subunit of RNA polymerase. Furthermore, 95.6{%} of the rifampin-resistant mutants obtained from 9 methicillin-resistant S. aureus (MRSA) clinical isolates showed decreased vancomycin susceptibilities. These data indicate the involvement of an rpoB mutation in VISA phenotype expression

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APA

Watanabe, Y., Cui, L., Katayama, Y., Kozue, K., & Hiramatsu, K. (2011). Impact of rpoB mutations on reduced vancomycin susceptibility in Staphylococcus aureus. Journal of Clinical Microbiology, 49(7), 2680–2684. https://doi.org/10.1128/JCM.02144-10

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