Background: Globally, chronic B viral hepatitis (HBV) is a major health<br />problem. Obesity is a common problem among patients with HBV. Several<br />studies have reported that obesity is an important risk factor that<br />alters immune system response in individuals with no underlying cause of<br />liver disease. However, there is a strong association between BMI and<br />the human immune system among HBV patients.<br />Objective: This study was to examine the correlation between body mass<br />index, serum alanine aminotransferase activity (ALT) and immunologic<br />response in obese hepatitis B patients.<br />Material and methods: One hundred fifty male patients with chronic<br />hepatitis B virus, their age ranged from 30 to 45 (38.64 +/- 7.12) years<br />and their BMI ranged from 30-35 kg/m(2). All Subjects were included in<br />two groups: The first group received weight reduction program in the<br />form of treadmill aerobic exercises in addition to diet control whereas<br />the second group received no therapeutic intervention. Parameters of<br />serum alanine aminotransferase (ALT), CD3, CD4 and CD8 were quantified;<br />Leukocyte, differential counts and body mass index (BMI) were measured<br />before and after 3 months at the end of the study.<br />Results: There was a 24.7%, 36.8%, 30.8%, 40.7%, 28.6%, 25.9%,<br />33.3% and 14.3 % reduction in mean values of alanine aminotransferase<br />(ALT), white blood cells, total neutrophil count, monocytes, CD3, CD4,<br />CD8 and BMI respectively in group (A) at the end of the study. In<br />addition, there were significant differences between mean levels of the<br />investigated parameters in groups.<br />Conclusion: Based on our findings, weight loss modulates serum alanine<br />aminotransferase and immune system parameters of patients with hepatitis<br />B virus infection.
Abd El-Kader, S. M., & Al-Dahr, M. H. S. (2016). Impact of weight reduction program on serum alanine aminotransferase activity and immunologic response in obese hepatitis B patients. African Health Sciences, 16(1), 128–134. https://doi.org/10.4314/ahs.v16i1.17