Implementation of a reference standard and proficiency testing programme by the World Wide Antimalarial Resistance Network (WWARN)

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Abstract

The Worldwide Antimalarial Resistance Network (WWARN) is a global collaboration to support the objective that anyone affected by malaria receives effective and safe drug treatment. The Pharmacology module aims to inform optimal anti-malarial drug selection. There is an urgent need to define the drug exposure - effect relationship for most anti-malarial drugs. Few anti-malarials have had their therapeutic blood concentration levels defined. One of the main challenges in assessing safety and efficacy data in relation to drug concentrations is the comparability of data generated from different laboratories. To explain differences in anti-malarial pharmacokinetics in studies with different measurement laboratories it is necessary to confirm the accuracy of the assay methods. This requires the establishment of an external quality assurance process to assure results that can be compared. This paper describes this process.

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Lourens, C., Watkins, W. M., Barnes, K. I., Sibley, C. H., Guerin, P. J., White, N. J., & Lindegardh, N. (2010). Implementation of a reference standard and proficiency testing programme by the World Wide Antimalarial Resistance Network (WWARN). Malaria Journal, 9(1). https://doi.org/10.1186/1475-2875-9-375

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