In this issue of Molecular Cell, Sampath et al. show a lysine methylase exhibits substrate promiscuity and variability in degree of product methylation (Sampath et al., 2007). Two lysines are found to be automethylated in G9a, and one is H3K9-like and can establish a docking site for HP1 chromodomain. © 2007 Elsevier Inc. All rights reserved.
Henkels, C. H., & Khorasanizadeh, S. (2007, August 17). Implications of a Histone Code Mimic in Epigenetic Signaling. Molecular Cell. https://doi.org/10.1016/j.molcel.2007.08.002