Memory loss is an early symptom of Alzheimer's Disease (AD). The findings of Gong et al. (2006) now indicate that enhancing the activity of UCH-L1, a ubiquitin hydrolase, alleviates the synaptic dysfunction and memory loss associated with a mouse model of AD. This work also raises the question of what role UCH-L1 might play in other diseases involving protein aggregation, such as Parkinson's Disease. © 2006 Elsevier Inc. All rights reserved.
Lansbury, P. T. (2006, August 25). Improving Synaptic Function in a Mouse Model of AD. Cell. https://doi.org/10.1016/j.cell.2006.08.011