The incidence of relative adrenal insufficiency in patients with septic shock after the administration of etomidate

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Abstract

Etomidate blocks adrenocortical synthesis when it is administered intravenously as a continuous infusion or a single bolus. The influence of etomidate administration on the incidence of relative adrenal insufficiency in patients with septic shock has not been formally investigated. The objective of this study was to determine the incidence of relative adrenal insufficiency in patients with septic shock after etomidate administration compared with patients with septic shock who did not receive etomidate.

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Mohammad, Z., Afessa, B., & Finkielman, J. D. (2006). The incidence of relative adrenal insufficiency in patients with septic shock after the administration of etomidate. Critical Care, 10(4). https://doi.org/10.1186/cc4979

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