No increase in autism-associated genetic events in children conceived by assisted reproduction

Citations of this article
Mendeley users who have this article in their library.


Objective To understand the rate of genetic events in patients with autism spectrum disorder (ASD) who were exposed to assisted reproduction. Design Case control study using genetics data. Setting Twelve collaborating data collection sites across North America as part of the Simons Simplex Collection. Patient(s) 2,760 children with ASD, for whom 1,994 had published copy number variation data and 424 had published gene mutation status available. Intervention(s) None. Main Outcome Measure(s) Rates of autism-associated genetic events in children with ASD conceived with assisted reproduction versus those conceived naturally. Result(s) No statistically significant differences in copy number variations or autism-associated gene-disrupting events were found when comparing ASD patients exposed to assisted reproduction with those not exposed to assisted reproduction. Conclusion(s) This is the first large genetic association to concurrently examine the genotype of individuals with ASD in relation to their exposure to ART versus natural conception, and it adds reassuring evidence to the argument that ART does not increase the risk of ASD. © 2014 by American Society for Reproductive Medicine.




Ackerman, S., Wenegrat, J., Rettew, D., Althoff, R., & Bernier, R. (2014). No increase in autism-associated genetic events in children conceived by assisted reproduction. Fertility and Sterility, 102(2), 388–393.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free