Increased biliary glutathione disulfide release in chronically ethanol-treated rats

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Abstract

Intoduction Glutathione &sulfide (GSSG) release frc3 liver [I ] has been evaluated as an indicator of oxidative stress, including lipid peroxidation (cf. hydroperoxide metabolism review in [2] )_ At present, the occurrence of enhanced rates of lipid peroxidation or of Ns02 production in the liver of rats c!lronically treated with ethanol is controversial (cf. review in ]3] and references therein) but appears to be a central concept in experimental pathology_ Therefore, we have applied a non-invasive approach and have examined the release of both oxidized and reduced ghrtathione from the liver of rats chronically treated, i.e., for 6 weeks with ethanol, essentially as in [4]. According to the finding that GSSG release occurs into bile [5], measurements were carried out in bile samples obtained from anesthetized rats.

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Sies, H., Koch, O. R., Martino, E., & Boveris, A. (1979). Increased biliary glutathione disulfide release in chronically ethanol-treated rats. FEBS Letters, 103(2), 287–290. https://doi.org/10.1016/0014-5793(79)81346-0

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