Influence of GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus and diabetic sensorimotor peripheral neuropathy risk

17Citations
Citations of this article
25Readers
Mendeley users who have this article in their library.

Abstract

<p> <italic>Background and Aims</italic> . Diabetic neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). Genetic susceptibility and oxidative stress may play a role in the appearance of T2DM and diabetic neuropathy. We investigated the relation between polymorphism in genes related to oxidative stress such as <italic>GSTM1</italic> , <italic>GSTT1</italic> , and <italic>GSTP1</italic> and the presence of T2DM and diabetic neuropathy (DN). <italic>Methods</italic> . Samples were collected from 84 patients with T2DM (42 patients with DN and 42 patients without DN) and 98 healthy controls and genotyped by using polymerase chain reaction and restriction fragment length polymorphism method. <italic>Results</italic> . <italic>GSTP1</italic> Ile105Val polymorphism was associated with the risk of developing T2DM ( <math id="M1"> <mi>p</mi> <mo>=</mo> <mn>0.05</mn> </math> ) but not with the risk of developing DN in diabetic cases. <italic>GSTM1</italic> and <italic>GSTT1</italic> gene polymorphisms were associated with neither the risk of developing T2DM nor the risk of DN occurrence in diabetic patients. No association was observed between the patients with T2DM and DSPN (diabetic sensorimotor peripheral neuropathy) and T2DM without DSPN regarding investigated polymorphism. <italic>Conclusion</italic> . Our data suggest that <italic>GSTP1</italic> gene polymorphisms may contribute to the development of T2DM in Romanian population. <italic>GSTM1</italic> , <italic>GSTT1</italic> , and <italic>GSTP1</italic> gene polymorphisms are not associated with susceptibility of developing diabetic neuropathy in T2DM patients. </p>

Cite

CITATION STYLE

APA

Stoian, A., Bənescu, C., Bəlaşa, R. I., Moţəţəianu, A., Stoian, M., Moldovan, V. G., … Dobreanu, M. (2015). Influence of GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus and diabetic sensorimotor peripheral neuropathy risk. Disease Markers, 2015. https://doi.org/10.1155/2015/638693

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free