The influence of P-light chain phosphorylation by myosin light chain kinase on the calcium sensitivity of chemically skinned heart fibres

64Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

Phosphorylation of the P-light chain of myosin might be involved in the regulation of cardiac contractility. Thus an enhanced phosphorylation level of the P-light chain catalyzed by Ca2+-calmodulin-dependent myosin light chain kinase (MLCK) increased significantly the Ca2+ sensitivity of chemically skinned ventricular fibre bundles of the pig. This effect was reversible. Whereas force development at submaximal Ca2+ concentration (pCa 5.5) increased by ~ 50% in the presence of MLCK, maximum tension achieved at maximum Ca2+-concentration (pCa 4.3) was not affected. © 1985.

Cite

CITATION STYLE

APA

Morano, I., Hofmann, F., Zimmer, M., & Rüegg, J. C. (1985). The influence of P-light chain phosphorylation by myosin light chain kinase on the calcium sensitivity of chemically skinned heart fibres. FEBS Letters, 189(2), 221–224. https://doi.org/10.1016/0014-5793(85)81027-9

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free