Inhibition of Endothelial Cell Apoptosis by Netrin-1 during Angiogenesis

Citations of this article
Mendeley users who have this article in their library.


Netrin-1 was recently proposed to play an important role in embryonic and pathological angiogenesis. However, data reported led to the apparently contradictory conclusions that netrin-1 is either a pro- or an antiangiogenic factor. Here, we reconcile these opposing observations by demonstrating that netrin-1 acts as a survival factor for endothelial cells, blocking the proapoptotic effect of the dependence receptor UNC5B and its downstream death signaling effector, the serine/threonine kinase DAPK. The netrin-1 effect on blood vessel development is mimicked by caspase inhibitors in ex vivo assays, and the inhibition of caspase activity, the silencing of the UNC5B receptor, and the silencing of DAPK are each sufficient to rescue the vascular sprouting defects induced by netrin-1 silencing in zebrafish. Thus, the proapoptotic effect of unbound UNC5B and the survival effect of netrin-1 on endothelial cells finely tune the angiogenic process. © 2009 Elsevier Inc. All rights reserved.

Author supplied keywords




Castets, M., Coissieux, M. M., Delloye-Bourgeois, C., Bernard, L., Delcros, J. G., Bernet, A., … Mehlen, P. (2009). Inhibition of Endothelial Cell Apoptosis by Netrin-1 during Angiogenesis. Developmental Cell, 16(4), 614–620.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free