Inhibition of taurocholate efflux from rat hepatic canalicular membrane vesicles by glutathione disulfide

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Abstract

In right-side out rat hepatic canalicular membrane vesicles glutathione disulfide (GSSG) inhibited the efflux of taurocholate approx. 70% in the presence or approx. 55% in the absence of a valinomycin-mediated K+ diffusion potential; maximal inhibition occurred at 5 mM GSSG. The inhibition by GSSG was abolished by dithioerythritol. Neither dithioerythritol alone nor GSH inhibited taurocholate efflux. S-(2,4-Dinitrophenyl) glutathione and N-ethylmaleimide showed intermediate inhibitory effects. © 1987.

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Griffiths, J. C., Sies, H., Meier, P. J., & Akerboom, T. P. M. (1987). Inhibition of taurocholate efflux from rat hepatic canalicular membrane vesicles by glutathione disulfide. FEBS Letters, 213(1), 34–38. https://doi.org/10.1016/0014-5793(87)81460-6

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