Inhibitory effect of the paraoxonase gene on the formation of rabbit coronary atherosclerosis

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Abstract

Objective: To observe the effect on the inhibition of coronary atherosclerosis hardening of the paraoxonase gene (PON-1) which transfected to the rabbit epicardial adipose tissue. Methods: Rabbit coronary atherosclerosis model was established by high-fat feeding, liposome-encapsulated recombinant plasmid pEGFP-PON-1 50 μ L was injected to the rabbit pericardial cavity, and was harvested 4 weeks after transfection. Results: The epicardial fat transfected PON-1 gene had effect on the high lipid level. It significantly increased expression of PON-1 in peripheral arterial vascular tissue (P <0.05); and significantly reduced total cholesterol and low-density lipoprotein cholesterol levels (P<0.05), and the thickness ratio of coronary artery intima/media (. P <0.05). Conclusions: The injection of the PON-1 gene in the pericardial cavity can effectively suppress the formation of coronary atherosclerosis. © 2013 Hainan Medical College.

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Bai, J., Zhou, H., Yang, X. H., Liu, H. F., & Meng, Y. Y. (2013). Inhibitory effect of the paraoxonase gene on the formation of rabbit coronary atherosclerosis. Asian Pacific Journal of Tropical Medicine, 6(7), 544–547. https://doi.org/10.1016/S1995-7645(13)60093-0

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