Integrated regulation of pressure and flow in the coronary microcirculation

84Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

Abstract

There are many mechanisms that contribute to the regulation of coronary blood flow including vasodilatory metabolites, myogenic regulation, flow- or shear stress-mediated vasodilation, and neurohumoral influences. It is interesting to note that coronary arterioles of varying sizes appear to possess different sensitivities to these regulatory factors, but each appears to dominate the control of a particular segment of the microvasculature. For example, during metabolic hyperemia the smallest arterioles seem to be most sensitive to the effects of metabolites, but metabolic and myogenic mechanisms that dictate the tone of upstream microvessels likely act in concert to facilitate the overall adjustments in coronary vasomotor tone. Neurohumoral mechanisms seem to modulate the robustness of these intrinisic adjustments, perhaps by restraining the extent of vasodilation. The purpose of this review is to discuss these many regulatory mechanisms and also present a framework by which the vasoactive reactions elicited by these different mechanisms are integrated into coordinated responses of the entire coronary vascular network.

Cite

CITATION STYLE

APA

Muller, J. M., Davis, M. J., & Chilian, W. M. (1996, October). Integrated regulation of pressure and flow in the coronary microcirculation. Cardiovascular Research. https://doi.org/10.1016/0008-6363(96)00111-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free