Adenoviral vectors used in gene therapy induce inflammation, although the underlying mechanisms are currently unknown. In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1α (IL-1α) in virus-induced inflammation and identify the β3 integrin as the key receptor regulating IL-1α activity. © 2009 Elsevier Inc. All rights reserved.
Fitzgerald, K. A. (2009, July 17). Integr-ating IL-1α in Antiviral Host Defenses. Immunity. https://doi.org/10.1016/j.immuni.2009.07.001