Interim estimates of 2013/14 vaccine effectiveness against influenza A(H1N1)PDM09 from Canada's sentinel surveillance network, January 2014

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Abstract

The 2013/14 influenza season to date in Canada has been characterised by predominant (90%) A(H1N1)pdm09 activity. Vaccine effectiveness (VE) was assessed in January 2014 by Canada's sentinel surveillance network using a test-negative case-control design. Interim adjusted-VE against medically-attended laboratory-confirmed influenza A(H1N1)pdm09 infection was 74% (95% CI: 58-83). Relative to vaccine, A(H1N1)pdm09 viruses were antigenically similar and genetically well conserved, with most showing just three mutations across the 50 amino acids comprising antigenic sites of the haemagglutinin protein.

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Skowronski, D. M., Chambers, C., Sabaiduc, S., De Serres, G., Dickinson, J. A., Winter, A. L., … Li, Y. (2014). Interim estimates of 2013/14 vaccine effectiveness against influenza A(H1N1)PDM09 from Canada’s sentinel surveillance network, January 2014. Eurosurveillance, 19(5). https://doi.org/10.2807/1560-7917.ES2014.19.5.20690

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