Interleukin-2-dependent regulation of Na/K pump in human lymphocytes

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The present study provides the first evidence that the abundance of catalytic α1-subunit of Na,K-ATPase increases in the course of T cell blast transformation. Immunodepressant cyclosporin A at anti-proliferative doses diminished the induction of α1 protein in activated lymphocytes. Furthermore, in competent T cells, IL-2 increases both the transport activity of Na/K pump and the content of Na,K-ATPase α1 protein in a time-dependent manner. A correlation was found between the long-term elevation in ouabain-sensitive Rb influxes and the increase in α1 protein content in late activated T cells. These results suggest that (1) the increased expression of Na,K-ATPase proteins underlie the cell cycle-dependent upregulation of ion pump during T cell transformation, and (2) IL-2 is involved in the regulated expression of Na,K-ATPase in human lymphocytes. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.




Marakhova, I., Karitskaya, I., Aksenov, N., Zenin, V., & Vinogradova, T. (2005). Interleukin-2-dependent regulation of Na/K pump in human lymphocytes. FEBS Letters, 579(13), 2773–2780.

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