Recent publications put a serious warning regarding the inefficacy of sulphadoxine-pyrimethamine (SP) for the intermittent preventive treatment of malaria in young children (IPTi). Recommendations for other therapies are being made. By using a different and better sulphonamide (sulphamethoxypyrazine), it is possible to manufacture fixed dose combination pills with artesunate and pyrimethamine. This combination permits a full therapy over 24 hours (dosing interval being 12 hours). It is recommended that this combination should be tested in future field studies of IPTi.
Jansen, F. H. (2011). Intermittent preventive therapy for malaria: Arguments in favour of artesunate and sulphamethoxypyrazine - Pyrimethamine combination. Malaria Journal. https://doi.org/10.1186/1475-2875-10-70