The interplay between the Bcl-2 family and death receptor-mediated apoptosis

Citations of this article
Mendeley users who have this article in their library.


Two principal pathways for apoptosis initiation exist. One pathway, which is also termed the 'extrinsic' pathway, is mediated by death receptors, a subgroup of the TNF receptor superfamily. The second pathway, which is also referred to as the 'intrinsic' pathway is controlled by members of the Bcl-2 family. A long standing discussion revolves around the question of how these two pathways influence each other in regulating the decision about life or death of a cell. Here, we review our current knowledge about the interactions between these two pathways and discuss current models which could help to resolve previous apparently contradictory results. © 2003 Elsevier B.V. All rights reserved.

Author supplied keywords




Sprick, M. R., & Walczak, H. (2004, March 1). The interplay between the Bcl-2 family and death receptor-mediated apoptosis. Biochimica et Biophysica Acta - Molecular Cell Research.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free