Interplay between polymerase II- and polymerase III-assisted expression of overlapping genes

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Abstract

Up to 15% of the genes in different genomes overlap. This architecture, although beneficial for the genome size, represents an obstacle for simultaneous transcription of both genes. Here we analyze the interference between RNA-polymerase II (Pol II) and RNA-polymerase III (Pol III) when transcribing their target genes encoded on opposing strands within the same DNA fragment in Arabidopsis thaliana. The expression of a Pol II-dependent protein-coding gene negatively correlated with the transcription of a Pol III-dependent, tRNA-coding gene set. We suggest that the architecture of the overlapping genes introduces an additional layer of control of gene expression. © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Lukoszek, R., Mueller-Roeber, B., & Ignatova, Z. (2013). Interplay between polymerase II- and polymerase III-assisted expression of overlapping genes. FEBS Letters, 587(22), 3692–3695. https://doi.org/10.1016/j.febslet.2013.09.033

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