Intramuscular midazolam for pediatric sedation in the emergency department: A short communication on clinical safety and effectiveness

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Abstract

BACKGROUND: Procedural sedation in children continues to be a problem in the emergency department (ED). Midazolam is the first water-soluble benzodiazepine and it has been widely used for procedural sedation in pediatric patients.<br /><br />OBJECTIVES: The aim of this study was evaluation of clinical safety and effectiveness of intramuscular Midazolam for pediatric sedation in the ED setting.<br /><br />MATERIALS AND METHODS: We performed a self-controlled clinical trial on 30 children who referred to the Baqiyatallah Hospital ED between 2009 and 2010. They received intramuscular Midazolam 0.3 mg/kg for procedural sedation and then they were followed for sedative effectiveness and safety. Vital signs and O2 saturation were also observed. The findings were compared using SPSS ver. 16 software.<br /><br />RESULTS: The mean age was 5.50 ± 2.70 years, the mean weight was 19.50 ± 6.63 kilograms and 16 patients (53.3%) were females. The most common adverse effect was euphoria (66.66%) and vertigo (6.7%); 27.7% did not show any side effects. There was an overall complication rate of 72.3%. The vital signs including heart rate, respiratory rate, systolic and diastolic blood pressure and O2 saturation decreased significantly during sedation (P value < 0.05).<br /><br />CONCLUSIONS: Midazolam is an effective and relatively safe sedative for pediatric patients in the ED. The patient should be observed closely and monitored for psychological and hemodynamic side effects.

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APA

Ghane, M. R., Vaezi, S. Y. M., Asl, A. A. H., Javadzadeh, H. R., Mahmoudi, S., & Saburi, A. (2012). Intramuscular midazolam for pediatric sedation in the emergency department: A short communication on clinical safety and effectiveness. Trauma Monthly, 17(1), 233–235. https://doi.org/10.5812/traumamon.3458

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