Senescence of mammalian cultured cells is essentially organized by a machinery of cell division and cellular stresses induced by various extracellular stimuli. Here, we show that in mouse embryonic fibroblasts (MEFs) culture in vitro, expression of an inflammatory cytokine, interleukin-1β (IL-1β) and its antagonist, IL-1 receptor antagonist (IL-1Ra) are induced by senescence. The kinetics of IL-1β-expression was similar to that of p38 activation during MEFs culture. We also found a distinguishable accelerated senescence in cell growth in IL-1Ra deficient MEFs culture. Our results suggest that IL-1β signaling pathway is involved in activation of p38 linked cellular senescence. © 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Uekawa, N., Nishikimi, A., Isobe, K. I., Iwakura, Y., & Maruyama, M. (2004). Involvement of IL-1 family proteins in p38 linked cellular senescence of mouse embryonic fibroblasts. FEBS Letters, 575(1–3), 30–34. https://doi.org/10.1016/j.febslet.2004.08.033