Involvement of leukotriene B4 in dermatophyte-related itch in mice

Citations of this article
Mendeley users who have this article in their library.
Get full text


Background Proteinase-activated receptor-2 (PAR2) is involved in dermatophyte-induced scratching and leukotriene B4 (LTB4) release from keratinocytes. We investigated whether PAR2-mediated LTB4 production is involved in dermatophyte-induced scratching. Methods Dermatophyte extract was injected intradermally and scratching was observed in mice. LTB4 was determined by enzyme immunoassay. Results Dermatophyte extract-induced scratching was inhibited by zileuton (5-lipoxygenase inhibitor), ONO-4057 (LTB4 antagonist), FSLLRY-NH2 (PAR2 antagonist), and anti-PAR2 antibody. Dermatophyte extract injection increased the cutaneous content of LTB4, which was inhibited by zileuton and FSLLRY-NH2. Conclusion These results suggest the involvement of LTB4 in dermatophyte-associated itch. LTB4 production might be due to PAR2 stimulation in the skin. © 2014 Institute of Pharmacology, Polish Academy of Sciences.




Andoh, T., Takayama, Y., & Kuraishi, Y. (2014). Involvement of leukotriene B4 in dermatophyte-related itch in mice. Pharmacological Reports, 66(4), 699–703.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free