Involvement of long non-coding RNA in colorectal cancer: From benchtop to bedside (Review)

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Abstract

© 2015, Spandidos Publications. All rights received. Colorectal cancer (CRC) is one of the greatest threats to public health. Recent advances in whole-genome transcriptome analyses have enabled the identification of numerous members of a novel class of non-coding (nc)RNA, long ncRNA (lncRNA), which is broadly defined as RNA molecules that are > 200 nt in length and lacking an open reading frame. In the present review, all lncRNAs associated with CRC are briefly summarized, with a particular focus on their potential roles as clinical biomarkers. CRC-associated lncRNAs involved in the underlying mechanisms of CRC progression are also initially included. This should benefit the development of novel markers and effective therapeutic targets for patients with CRC.

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Ye, L. C., Zhu, D. X., Qiu, J. J., Xu, J., & Wei, Y. (2015, March 1). Involvement of long non-coding RNA in colorectal cancer: From benchtop to bedside (Review). Oncology Letters. Spandidos Publications. https://doi.org/10.3892/ol.2015.2846

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