Isolation and Structure Elucidation of Onnamide A, a New Bioactive Metabolite of a Marine Sponge, Theonella SP

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Abstract

Marine sponges of the genus Theonella , collected at a coral reef of Kerama, Okinawa, have been shown to elaborate diverse chemical structures with interesting biological activities. The authors have recently described the isolation of misakinolide A, a dimeric 40-membered lactone having antitumor activity from a species of Theonella . In screening for bioactivity in marine organisms occurring in Okinawan waters, another species of Theonella gave an extract showing antiviral activity. Bioassay-guided separation led to the isolation of an active constituent, onnamide A which belonged to a class of metabolites new to Theonella species. The authors herein report the isolation and structure elucidation of onnamide A.

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Sakemi, S., Ichiba, T., Kohmoto, S., Saucy, G., & Higa, T. (1988). Isolation and Structure Elucidation of Onnamide A, a New Bioactive Metabolite of a Marine Sponge, Theonella SP. Journal of the American Chemical Society, 110(14), 4851–4853. https://doi.org/10.1021/ja00222a068

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