Mechanism of action studies are essential to link observable effects on cells with molecular targets of small molecules. Caligiuri and coworkers  describe how yeast three-hybrid screening identified kinases that might mediate an intriguing tumor cell-specific antiproliferative effect. ©2005 Elsevier Ltd All rights reserved.
Toogood, P. L. (2005, October). The kinome is not enough. Chemistry and Biology. https://doi.org/10.1016/j.chembiol.2005.09.011