Knock-down of LAR protein tyrosine phosphatase induces insulin resistance

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To test the role of the leukocyte common antigen-related protein tyrosine phosphatase (LAR) as a regulator of insulin receptor (IR) signalling, an siRNA probe against LAR was developed. Knock-down of LAR induced post-receptor insulin resistance with the insulin-induced activation of PKB/Akt and MAP kinases markedly inhibited. The phosphorylation and dephosphorylation of the IR and insulin receptor substrate (IRS) proteins were unaffected by LAR knock-down. These results identify LAR as a crucial regulator of the sensitivity of two key insulin signalling pathways to insulin. Moreover, the siRNA probe provides a molecular tool of general applicability for further dissecting the precise targets and roles of LAR. © 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.




Mander, A., Hodgkinson, C. P., & Sale, G. J. (2005). Knock-down of LAR protein tyrosine phosphatase induces insulin resistance. FEBS Letters, 579(14), 3024–3028.

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