Labor Augmentation with Oxytocin Decreases Glutathione Level

  • Schneid-Kofman N
  • Silberstein T
  • Saphier O
  • et al.
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Abstract

Objective . To compare oxidative stress following spontaneous vaginal delivery with that induced by Oxytocin augmented delivery. Methods . 98 women recruited prior to labor. 57 delivered spontaneously, while 41 received Oxytocin for augmentation of labor. Complicated deliveries and high-risk pregnancies were excluded. Informed consent was documented. Arterial cord blood gases, levels of Hematocrit, Hemoglobin, and Bilirubin were studied. Glutathione (GSH) concentration was measured by a spectroscopic method. Plasma and red blood cell (RBC) levels of Malondialdehyde indicated lipid peroxidation. RBC uptake of phenol red denoted cell penetrability. SPSS data analysis was used. Results . Cord blood GSH was significantly lower in the Oxytocin group ( mM versus mM, ). No differences were found in plasma or RBC levels of MDA or in uptake of Phenol red between the groups. Conclusion . Lower GSH levels following Oxytocin augmentation indicate an oxidative stress, though selected measures of oxidative stress demonstrate no cell damage.

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Schneid-Kofman, N., Silberstein, T., Saphier, O., Shai, I., Tavor, D., & Burg, A. (2009). Labor Augmentation with Oxytocin Decreases Glutathione Level. Obstetrics and Gynecology International, 2009, 1–4. https://doi.org/10.1155/2009/807659

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