Lower body negative pressure (LBNP) has been used for decades to simulate orthostatic stress and the effects of blood loss in humans. Since the definitive review of LBNP in 1974, new applications have been developed and research has revealed conflicting cardiovascular and neurohormonal responses during and after LBNP.
Goswami, N., Loeppky, J. A., & Hinghofer-Szalkay, H. (2008, May). LBNP: Past protocols and technical considerations for experimental design. Aviation Space and Environmental Medicine. https://doi.org/10.3357/ASEM.2161.2008