Leptin keeps working, even in obesity

Abstract

The concept of leptin resistance posits that elevated endogenous leptin fails to decrease food intake in obese animals due to diminished leptin signaling. In this issue, Ottaway et al. (2015) use leptin antagonists to reveal persistence (or even elevation) of endogenous leptin signaling and physiologic action in diet-induced obesity. The concept of leptin resistance posits that elevated endogenous leptin fails to decrease food intake in obese animals due to diminished leptin signaling. In this issue, Ottaway et al. use leptin antagonists to reveal persistence (or even elevation) of endogenous leptin signaling and physiologic action in diet-induced obesity.