Sir, The recent study by Perry et al. (2014) draws attention to the important issue of abnormally enhanced reward-seeking by pa-tients with frontotemporal dementia (FTD). This issue presents major challenges for the clinical management of these patients and provides a unique window on the neurobiology of brain net-work disintegration in a diverse group of neurodegenerative pathologies. While Perry and colleagues emphasize seeking of sti-muli with clear biological reward potential (sweet foods, drugs of abuse and sex), abnormal reward-seeking in FTD is not restricted to such stimuli. Indeed, one of the most potent inducers of such behaviour in patients with FTD is a stimulus with no clear biolo-gical value: music. Abnormal, intense craving for music (musico-philia) is common in FTD and has a cerebral correlate centred on the mesial temporal lobe (Fletcher et al., 2013). Both in functional imaging studies of the healthy brain and in neurodegenerative disease (Omar et al., 2011; Salimpoor et al., 2013; Clark et al., 2014), music has been shown to engage striatal and basal forebrain regions overlapping or intimately connected with those demonstrated by Perry et al. (2014), in addition to a distributed network of cortical and limbic structures. Why music should behave as a biologically rewarding stimulus remains unre-solved although clues may lie with its capacity to encode emo-tional mental states (Clark et al., 2014): a cognitive process that is also often catastrophically disrupted in FTD. We therefore suggest music as a promising candidate model system for addressing some of the key questions for future work raised by the study of Perry and colleagues. In particular, as a universal and widely valued, yet abstract stimulus, music is ideally suited to probe interactions between reward, affective and cortical information processing circuitry (Omar et al., 2011; Salimpoor et al, 2013). This circuitry is inherently vulnerable in FTD. Moreover, a stimulus that can dissect apart the components of such large-scale brain networks may enable hedonic and physio-logical phenotyping of a range of other neurodegenerative dis-orders (including Parkinson's disease) that also cause profound derangements of reward processing.
Fletcher, P. D., Clark, C. N., & Warren, J. D. (2014). Letter to the editor: Music, reward and frontotemporal dementia. Brain. Oxford University Press. https://doi.org/10.1093/brain/awu145