Limitations of gene duplication models: Evolution of modules in protein interaction networks

6Citations
Citations of this article
29Readers
Mendeley users who have this article in their library.

Abstract

It has been generally acknowledged that the module structure of protein interaction networks plays a crucial role with respect to the functional understanding of these networks. In this paper, we study evolutionary aspects of the module structure of protein interaction networks, which forms a mesoscopic level of description with respect to the architectural principles of networks. The purpose of this paper is to investigate limitations of well known gene duplication models by showing that these models are lacking crucial structural features present in protein interaction networks on a mesoscopic scale. This observation reveals our incomplete understanding of the structural evolution of protein networks on the module level. © 2012 Emmert-Streib.

Cite

CITATION STYLE

APA

Emmert-Streib, F. (2012). Limitations of gene duplication models: Evolution of modules in protein interaction networks. PLoS ONE, 7(4). https://doi.org/10.1371/journal.pone.0035531

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free