LINE1 family member is negative regulator of HLA-G expression

Citations of this article
Mendeley users who have this article in their library.


Class Ia molecules of human leucocyte antigen (HLA-A,-B and-C) are widely expressed and play a central role in the immune system by presenting peptides derived from the lumen of the endoplasmic reticulum. In contrast, class Ib molecules such as HLA-G serve novel functions. The distribution of HLA-G is mostly limited to foetal trophoblastic tissues and some tumour tissues. The mechanism required for the tissue-specific regulation of the HLA-G gene has not been well understood. Here, we investigated the genomic regulation of HLA-G by manipulating one copy of a genomic DNA fragment on a human artificial chromosome. We identified a potential negative regulator of gene expression in a sequence upstream of HLA-G that overlapped with the long interspersed element (LINE1); silencing of HLA-G involved a DNA secondary structure generated in LINE1. The presence of a LINE1 gene silencer may explain the limited expression of HLA-G compared with other class I genes. © 2012 The Author(s).




Ikeno, M., Suzuki, N., Kamiya, M., Takahashi, Y., Kudoh, J., & Okazaki, T. (2012). LINE1 family member is negative regulator of HLA-G expression. Nucleic Acids Research, 40(21), 10742–10752.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free