Longitudinal Lung Function Growth of Mexican Children Compared with International Studies

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INTRODUCTION: Our aim was to compare the longitudinal lung function growth of Mexican children and adolescents with the collated spirometric reference proposed for international use and with that of Mexican-Americans from the National Health State Examination Survey III (NHANES) III study.<br /><br />MATERIALS AND METHODS: A cohort of Mexican children in third year of primary school was followed with spirometry twice a year through secondary school. Multilevel mixed-effects lineal models separated by gender were fit for the spirometric variables of 2,641 respiratory-healthy Mexican children expressed as Z-scores of tested reference equations. Impact of adjustment by sitting height on differences with Mexican-American children was observed in a subsample of 1,987 children.<br /><br />RESULTS: At same gender, age, and height, Mexican children had increasingly higher forced expiratory volume in 1 s (FEV1) and Forced vital capacity (FVC) than the children from the collated reference study (mean Z-score, 0.68 for FEV1 and 0.51 for FVC) and than Mexican-American children (Z-score, 0.23 for FEV1 and 0.21 for FVC) respectively. Differences with Mexican-Americans were not reduced by adjusting by sitting height.<br /><br />CONCLUSIONS: For reasons that remain unclear, the gender-, age-, and height-adjusted lung function of children from Mexico City is higher than that reported by several international studies.




Martínez-Briseño, D., Fernández-Plata, R., Gochicoa-Rangel, L., Torre-Bouscoulet, L., Rojas-Martínez, R., Mendoza, L., … Pérez-Padilla, R. (2013). Longitudinal Lung Function Growth of Mexican Children Compared with International Studies. PLoS ONE, 8(10). https://doi.org/10.1371/journal.pone.0077403

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