Long-term weight maintenance after a 17-week weight loss intervention with or without a one-year maintenance program: A randomized controlled trial

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Abstract

Background . Weight lost by obese patients is almost always regained over time. Extended treatment may improve maintenance, but solid evidence is lacking. Purpose . We determined effectiveness of maintenance therapy after a weight loss program. Methods . Together 201 patients (mean age 47 years and BMI 42 kg/m 2 , 71% women) were randomly assigned to either a 17-week weight loss program followed by a one-year maintenance program or to a weight loss program without subsequent maintenance intervention. The weight loss program included behavior modification and a very-low-calorie diet, and maintenance program behavior modification. The primary outcome measure was percentage of patients with 5% or more weight loss at the end of maintenance (week 69) and one year later (week 121). Secondary outcomes were weight related changes in lifestyle and quality of life. Results . At week 69, 52% of the patients with and 44% of those without maintenance program had lost weight ≥ 5%, P=0.40 , and, at week 121, 33% and 34%, P=0.77 , respectively. At week 121 secondary outcomes did not differ between the groups among those successfully followed up. Conclusions . This one-year maintenance program was not effective in preventing weight regain in severely obese patients. Trial Registration . This trial is registered under clinicaltrials.gov Identifier: NCT00590655 .

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Pekkarinen, T., Kaukua, J., & Mustajoki, P. (2015). Long-term weight maintenance after a 17-week weight loss intervention with or without a one-year maintenance program: A randomized controlled trial. Journal of Obesity, 2015. https://doi.org/10.1155/2015/651460

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